San Jose took a 1-0 lead at 4:50 of the first period on Meier's second goal of the season. Danny O'Regan won a battle for the puck behind the net and sent a cross-crease pass to Meier, who beat Khudobin with a wrist shot.
Cehlarik tied it 1-1 at 6:17 of the first period. Dell stopped DeBrusk's initial shot off a rush, but Cehlarik scored on the rebound.
Dell was knocked to the ice before Cehlarik scored, and Sharks coach Peter DeBoer challenged for goaltender interference. The goal stood after it was determined Joakim Ryan tripped DeBrusk, sending him into Dell.
"I took a swipe at the puck, and I guess my stick hit [DeBrusk's] skates," Ryan said.
The Sharks had two goals negated on coach's challenges in a 2-0 loss to the Florida Panthers on Thursday. They had two reviews go against them Saturday.
DeBrusk scored on a breakaway at 10:46, three seconds after a Sharks power play expired, to give the Bruins a 2-1 lead. Charlie McAvoy cleared the puck deep down the right side, and DeBrusk tracked it down and beat Dell to the far side.
"It was a weird play from the start," DeBrusk said. "I remember Charlie kind of shot it out. I think it hit a stanchion or something or off the glass even, because I didn't even know where the puck was. I looked and it was kind of traveling to that dot area. I thought for sure [Dell] was going to come out, but it's a pretty fast game out there."