Matthews, who was named to his fourth All-Star Game but did not play because of an ailing right wrist, was in St. Louis this weekend and wore a wrist brace while visiting with all-star teammates Frederik Andersen and Mitch Marner on Friday.
Although the forward said that his wrist is not 100 percent, he said he could feel improvement during Toronto's practice in Nashville on Sunday.
"I feel good," Matthews said. "I feel a lot better than the previous week, so all signs point towards playing tomorrow. I thought today's practice was a good sign."
So did Maple Leafs coach Sheldon Keefe.
"Based on how he looked on the ice today and my conversation with him, I would say (I have) a low level of concern for him," Keefe said. "The time away seemed to help and it's looking like he's ready to play."
Matthews leads the Maple Leafs in goals (34) and points (57) in 49 games. He is on pace for 57 goals this season, which would make him the fourth player in Toronto history to score at least 50, joining Rick Vaive (54 in 1981-82, 51 in 1982-83 and 52 in 1983-84), Gary Leeman (51 in 1989-90) and Dave Andreychuk (53 in 1993-94).