The Maple Leafs, who trail the Boston Bruins by nine points for second place in the Atlantic Division with Boston holding two games in hand, are 0-2-2 in their past four games and have not lost five in a row since Feb. 23-March 3, 2017 (0-2-3).
With a victory, Toronto would set a record with its 10th consecutive home win; the Maple Leafs mark is nine straight home victories, set from Nov. 11-Dec. 26, 1953 and tied from March 6-April 7, 2007.
Center Auston Matthews will miss his sixth straight game with a shoulder injury.
Goaltender Tristan Jarry will start for the Penguins, who seek their fourth straight win following a three-game losing streak (0-3-0). Pittsburgh, 14-4-1 in its past 19 games, trails the Washington Capitals by one point for first place in the Metropolitan Division.