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Bonino was on the ice briefly during warmups but was scratched for the second straight game.
He has been using crutches and wearing a walking boot on his left foot after he was injured blocking a shot by Nashville defenseman P.K. Subban in the first period of Game 2 on Wednesday.
Bonino, who did not play in a 5-1, Game 3 loss on Saturday, practiced Sunday but didn't participate in the optional morning skate Monday. He was seen leaving the arena using the crutches and wearing the boot at the same time several Penguins were on the ice for the morning skate.
Pittsburgh leads the best-of-7 series 2-1. Game 5 is Thursday.
Bonino scored two goals in Game 1, a 5-3 Pittsburgh win, and has seven points in 21 games in the 2017 Stanley Cup Playoffs.
