Carolina is third in the Metropolitan Division, one point ahead of the Pittsburgh Penguins and Columbus Blue Jackets, after a 5-2 victory against the St. Louis Blues on Friday.
Goalie Petr Mrazek is expected to start for the Hurricanes, who are 7-1-0 in their past eight games and 12-3-1 in their past 16.
The Panthers, who trail Columbus by nine points for the second wild card into the Stanley Cup Playoffs from the Eastern Conference, have lost two straight games in a shootout (4-3 at the Arizona Coyotes on Tuesday and 6-5 at the Vegas Golden Knights on Thursday.)
Florida has scored 34 goals while going 5-1-2 in its past eight games.