The Habs and Pens will also meet again next week, on March 31, to wrap up their three-game season series.
On Tuesday after practice, Claude Julien confirmed that Carey Price will get the start at PPG Paints Arena -- his first start since suffering a concussion on Feb. 20 in Philadelphia.
Price returned to practice last week, and served as Antti Niemi's backup against the Florida Panthers on Monday.
Alex Galchenyuk meanwhile, who left practice early on Tuesday with a hand injury, will be re-evaluated prior to puck drop in Pittsburgh.
Julien hinted that a lineup change could be possible if the 24-year-old is not ready to face the Pens at game time.
At the other end of the ice, Pittsburgh is coming off a 4-1 loss in Brooklyn on Tuesday.
Evgeni Malkin, who registered a goal and an assist in the Pens' win in Montreal last week, leads the team with 89 points (40G-49A) this season. He's likewise fourth overall in the NHL in that category.
With a 41-27-5 record, the Penguins currently sit second in the Metropolitan Division, four points back of the Washington Capitals.
Wednesday's game is scheduled for 7:00 p.m. in Pittsburgh, and will be broadcast on Sportsnet, RDS, TSN690 and 98,5 fm in Canada.
