Scandella last played on April 26 against the Colorado Avalanche and has missed three games with the injury.
Game 3 of the best-of-7 series between the St. Louis Blues and Minnesota Wild, which is tied 1-1, begins at 8:30 p.m. Friday (BSMW, TNT, 101 ESPN).
If Scandella can't play, Berube will need to bring defenseman Steven Santini into the lineup in his absence.
Santini was recalled from the AHL's Springfield Thunderbirds on Thursday under emergency conditions. He played 66 regular-season games with the Thunderbirds, posting two goals, 16 assists (18 points) and a plus-16 rating. He also played in three-regular season games and two postseason contests with the Blues in 2020-21 but has not made an appearance with the club this year. Overall, Santini has 119 games of NHL experience between the Blues, Nashville Predators and New Jersey Devils.
He was skating with Calle Rosen on the team's third defense pairing on Friday, which will be his likely spot if Scandella is unable to play.
"He's just a stay-at-home D-man, plays hard around the net," Berube said of Santini. "He's a disciplined player. Simple puck movement, he plays a hard game, he's going to get in the way, be physical, block shots, those types of things."
Berube also will be making a change up front, replacing Nathan Walker with Dakota Joshua to bring more heaviness to the fourth line.
"(Joshua brings) heaviness, size, he can skate well, gets on top of people," Berube said. "It's a good-sized line (now) with a veteran centerman that can do the job in their own zone."
Below is a projected lineup for Game 3 based on Friday's morning skate.