It didn't take Columbus long to jump on the visitors, scoring goals at 1:03 and 3:13 to take a 2-0 lead.
Del Zotto got the party started after the Jackets had three scoring chances in the first minute, as Alexandre Texier fed him a puck at the left point and he scored through a screen off the glove of Chicago goalie Kevin Lankinen to make it 1-0. Just over two minutes later, Roslovic fired a centering pass from the right-wing wall and Atkinson was alone in front to force the puck past Lankinen and over the line to tie the score.
But a pair of back-to-back penalties on the Blue Jackets changed the momentum of the game near the midway point of the game. Columbus survived 38 seconds of a 5-on-3 thanks to big stops by Elvis Merzlikins on Patrick Kane and Kirby Dach, but Alex DeBrincat made it a 2-1 game with just six seconds left on the second penalty as he hammed a one-timer past te CBJ goalie from the left circle. The goal, off a pass from Calvin de Haan, came at 10:13 and made it 2-1.
The Blackhawks then tied the score with 2:58 left in the period moments after a CBJ icing. Carl Soderberg won the faceoff and eventually scored, as a shot from the pinballed toward the net and Soderberg jammed it home right as Merzlikins reached to poke-check it away.
Chicago then kept the momentum going through the second period, creating a number of transition chances and taking a 4-2 lead in the frame. The go-ahead goal came just 3:07 into the period, as Wyatt Kalynuk fired from the right point and the puck got behind Merzlikins through a screen. Kevin Stenlund tried to keep the puck out but it crossed the line by an inch before the CBJ forward slid it under Merzlikins to cover it. Columbus also challenged for goaltender interference but the league ruled there was incidental contact between Merzlikins and Pius Suter.
Columbus had a chance to tie later in the period when Kole Sherwood used his speed to create a breakaway, but Lankinen made a shoulder save on his shot. Then the Blackhawks doubled their lead at 16:40 on a beautiful transition goal, with DeBrincat feeding Dach in the middle of the ice before a pass to Dylan Strome in the right circle led to a one-timer past Merzlikins to make it 4-2.
The Blue Jackets had so thrust to start the third period with Alexandre Texier firing wide in transition, then Del Zotto and Oliver Bjorkstrand being denied by Lankinen after Chicago turnovers, and those saves were huge for the Blackhawks to keep the 4-2 lead. Del Zotto also set up Max Domi with just over six minutes left, but Lankinen stopped his try as part of a big third period for the Chicago goalie.
Patrik Laine did beat the Chicago goalie with 49.0 seconds left and an extra attacker on the ice off a cross-zone feed from Domi for his first goal since March 11. That made it 4-3, but that was as close as Columbus would get.