The visitors got on the board early and often in the opening period, striking first at the 3:16 mark. Roman Josi weaved his way through the slot and fired a wrister on goal that deflected off the leg of Viktor Arvidsson and in for a 1-0 Predators lead.
Colin Blackwell scored his first NHL goal at 8:22 of the opening period as Yakov Trenin won a puck back along the goal line and found the trailing Blackwell on the doorstep for a 2-0 lead.
Nashville made it 3-0 as Matt Duchene scored his 10th of the season at 16:55 of the first. Mattias Ekholm intercepted a pass at the Blackhawks blue line and quickly found Duchene lurking behind Chicago's defensemen, where the center put a deke on Crawford and slid a shot home.
The Blackhawks got on the board in the middle frame as Kubalik notched his 14th goal of the season, two off the rookie scoring lead. Jonathan Toews had the puck poke-checked off his stick in a 2-on-2 rush, but the trailer Kubalik picked it up in stride and beat Pekka Rinne with a wrister to cut the Predators' lead to 3-1 at 6:34.