Crosby, who is second on the Penguins with 31 points (12 goals, 19 assists) in 30 games, had four points (two goals, two assists) in three games against the Maple Leafs last season.
Matthews, who leads the Maple Leafs with 26 points (13 goals, 13 assists) in 25 games, had two points (one goal, one assist) in three games against the Penguins last season.
Toronto won two of the three games between the teams last season. The Maple Leafs lost 4-1 in Pittsburgh on Nov. 12, 2016, won 2-1 in overtime in Toronto on Dec. 17, 2016, and won 5-3 to clinch a spot in the Stanley Cup Playoffs in Toronto on April 8.