Tyson Foerster scored twice for the Flyers (40-26-12), and Matvei Michkov had two assists. Dan Vladar made 23 saves for Philadelphia, which is 6-2-0 in its past eight games and has won 15 of 21 (15-5-1).
Cody Glass scored for the Devils (40-35-3), who were eliminated from Stanley Cup Playoff contention. Jacob Markstrom made 14 saves.
It was the first game for the Devils since general manager Tom Fitzgerald was fired on Monday after 11 seasons with the team, including the past five as GM and executive vice president.
Zegras gave the Flyers a 1-0 lead 1:56 into the game, scoring from the right circle off a pass from Travis Sanheim. Owen Tippett started the play by cycling around the net and passing to Sanheim in the left circle.
Zegras scored his second of the period and NHL career-high 25th for a 2-0 lead with a power-play goal at 3:38, tipping in a pass from Porter Martone.
Glass got the Devils within one at 12:12 when Jonas Siegnthaler's shot from the slot deflected off a jumping Glass, then off Vladar's mask and into the net.
Foerster made it 3-1 at 2:46 of the second period, scoring on a 2-on-1 with Tippet when he kept the puck and took a wrist shot from the right circle.
Foerster scored again at 4:58 for a 4-1 advantage, converting a tic-tac-toe passing play with Zegras and Michkov. With the assist, Zegras tied his career high of 65 points (2022-23 with the Anaheim Ducks).
Nick Seeler scored an empty-net goal from his own zone at 17:09 for the 5-1 final.
