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"I've had the last two days to get plenty of treatment," Ryan said after the morning skate. "I feel good and I'm ready to go."
Ryan has eight points (four goals, four assists) in nine playoff games, which is tied with Karlsson and center Derick Brassard for the Senators lead.
Zack Smith, who sustained an upper-body injury during Game 3, will be a game-time decision.
"In the shorter period of time it'll be nice to have a few more hours to help make that decision, see how I feel tonight," Smith said.
Coach Guy Boucher said forward Tom Pyatt and defenseman Chris Wideman would be in the lineup. Wideman will replace Fredrik Claesson. Boucher opted to scratch Claesson, rather than rookie Ben Harpur, because Boucher likes Harpur's size (6-foot-6, 222 pounds).
Pyatt last played in Game 4 of the first round against the Boston Bruins, when he sustained an upper-body injury. He'll replace Smith if he can't play. If Smith can play, Boucher did not reveal which forward would come out of the lineup.
With the Senators continuing to win, Boucher did not want to upset what was working and alter his lineup to insert Pyatt.
"I feel good," Pyatt said. "I'm excited to get back in. Watching games gets a little old. You want to be a part of the playoffs, and it [stinks] when you're missing out. Just looking forward to tonight."
