Florida Panthers at Carolina Hurricanes, 5 p.m. ET (NHLN, FS-CR, FS-F, NHL.TV)
This is the second of four straight road games for the Panthers. They are 4-0-1 on the road; the Hurricanes are 4-0-0 at home.
Ottawa Senators at Toronto Maple Leafs, 7 p.m. ET (SN, TVAS, NHL.TV)
Senators forward Evgenii Dadonov has scored five goals in his past five games, including the game-tying and game-winning goals in a 6-5 overtime victory against the Maple Leafs on Monday.
Chicago Blackhawks at Detroit Red Wings, 7:30 p.m. ET (NBCSN)
Blackhawks forward Patrick Kane is fourth in the NHL with 22 points (seven goals, 15 assists) and has seven multiple-point games this season.
Vancouver Canucks at Calgary Flames, 10 p.m. ET (SN1, SNP, NHL.TV)
The Flames have won four of their past five games (4-1-0), including a 4-3 overtime victory against the Canucks on Monday.
Winnipeg Jets at Edmonton Oilers, 10 p.m. ET (NBCSN, TVAS, SNW, TSN3, NHL.TV)
Oilers center Connor McDavid has scored 499 points in the NHL (171 goals, 328 assists). If he scores a point Wednesday, he'll tie Pittsburgh Penguins center Sidney Crosby among active players for fewest games to reach 500 points (369).