Hornqvist, who participated in Pittsburgh's morning skate Monday, left 49 seconds into the third period of a 4-3 loss to the Toronto Maple Leafs on Saturday after taking a puck to the side of his head. He has eight points (four goals, four assists) in his past eight games despite being held without a point in his past two.
Pittsburgh is 2-2-0 in its first four games of a five-game homestand. The Penguins have lost two of their past three games but are 5-2-0 in their past seven after going 2-4-1 in their previous seven.
The Avalanche are 1-4-0 in their past five games but are coming off a 7-3 win at the Florida Panthers on Saturday. Forward Matt Nieto had three points (one goal, two assists) in that game.