Cale Makar tied the game 3-3 with a power-play goal with eight seconds remaining in the third period for Colorado on a wrist shot from the point on a 6-on-4 advantage. Makar pump-faked Predators forward Michael McCarron at the point and his wrist shot beat Saros on the glove side.
Brady Skjei, Jonathan Marchessault and Reid Schaefer scored for the Predators (11-14-4), who have won three of their past four games.
Nathan MacKinnon had two assists in his 900th NHL game for the Avalanche (21-2-7), who have points in 20 of their past 21 games (16-1-4). Scott Wedgewood made 26 saves in his return to the lineup after he missed the previous three games because of a back injury.
Skjei gave the Predators a 3-2 lead at 12:58 of the third period on a wrist shot from the point that got through traffic in front.
Brock Nelson gave the Avalanche a 1-0 lead at 1:12 of the first period on a backhand shot from the slot. He made a forehand-to-backhand move to get around Predators defenseman Roman Josi.
Marchessault scored for the Predators to make it 1-1 at 4:05 on a rebound of his own shot on Wedgewood’s glove side.
Schaefer gave the Predators a 2-1 lead at 5:30 of the first period on a power move to the net that beat Wedgewood on the blocker side.
Artturi Lehkonen scored for the Avalanche to make it 2-2 at 10:21 of the second period on a rebound of a shot from Martin Necas. MacKinnon had his first assist to become the first player in the NHL to reach 50 points this season.
