Strome tied it 1-1 at 3:35 of the second period from the slot after a backhanded pass from Poehling.
The Blue Jackets then went up 3-1 on goals 19 seconds apart by Werenski and Jenner.
“The second period we just let off for a little bit,” LaCombe said. “I think we've got to play a full 60 minutes. Obviously, they're a good team but there's areas we can improve on.
“We're kind of in and out of games right now. It feels like it's every other game we're playing strong. But we've done a lot of things well. We've just got to keep going.”
Werenski scored on the rush from the right circle for his second goal of the game at 3:59. Jenner then put in his own rebound at 4:18 after tipping a shot by Ivan Provorov.
“We need to put points in the bank here before the (holiday) break and knew how much is at stake here in these games, so I thought it was a resilient win,” Jenner said. “We just stuck with it, even when they get that one in the third. So, it’s something to build off.”
Granlund cut it to 3-2 at 5:29 with a wrist shot from the left circle.
“Definitely a weird moment there, kind of trading goals,” Werenski said. “But it's part of the game, and in an 82-game season, stuff like that's going to happen.
“I just felt like the whole time we were in control and comfortable, and that's a step in the right direction for this group.”
NOTES: Werenski has 20 points (seven goals, 13 assists) during an 11-game home point streak. He also reached the 10-goal mark for the eighth time in his career and matched John Carlson for the most by an active American defenseman. … Werenski played his 600th career game, moving past Nick Foligno for fourth on the all-time Blue Jackets list. Jenner, who is first, played his 760th game. … The Ducks and Blue Jackets play again in Anaheim on Saturday.