St. Louis is 8-0-2 in its past 10 road games. Its longest streak away from home came during the 1999-00 season, when it was 10-0 with one tie.
The Blues have outscored their opponents 16-6 in four straight wins including a 5-2 victory against the Penguins at Enterprise Center on Saturday.
Pittsburgh has lost two straight after winning its previous three and is 4-3-3 in its past 10 games. It's 6-0-2 on an eight-game home point streak since a 3-0 loss to the Vegas Golden Knights on Oct. 19, the longest since winning 11 in a row from Jan. 1 to Feb. 17, 2018.
The Penguins will play without forward Patric Hornqvist, who will be out longer-term after sustaining a lower-body injury in practice Monday.