Marchand has 20 points (seven goals, 13 assists) and Pastrnak has 23 points (11 goals, 12 assists) in the forwards' respective streaks for the Bruins, who seek their fourth straight victory.
The Sharks, 1-3-1 in their past five games, will try to avoid their third consecutive loss.
The game will feature the top three active members of the NHL all-time games played list. San Jose forwards Patrick Marleau (1,665 games, 40 years old) and Joe Thornton (1,578, 40) and Bruins defenseman Zdeno Chara (1,496, 42) will play in the first NHL game with three players at least 40 years old since March 4, 2014 (New Jersey Devils' Jaromir Jagr, 42, and Martin Brodeur, 41; Detroit Red Wings' Daniel Alfredsson, 41).