Pickard will make his first start since allowing six goals on 28 shots in a 6-3 loss to the Columbus Blue Jackets on Oct.18. He's 2-1-0 with a 4.75 goals-against average and .833 save percentage.
The Flyers have won the first two of their four-game Western trip, defeating the Anaheim Ducks 3-2 on Tuesday and the Los Angeles Kings 5-2 on Thursday.
Martin Jones will start for the Sharks, who have lost back to back games, both at home. Jones is 4-0-1 with a 2.36 GAA in his past five starts.
Sharks center Logan Couture has five goals and eights assists in an eight-game point streak, tying a career high.
The Sharks defeated Philadelphia 8-2 on Oct. 9 at Wells Fargo Center.