Connor Murphy will be out 10-14 days with a right hip injury.
The defenseman, who last played in a 2-1 overtime win against the Dallas Stars on Sunday, will miss his second consecutive game when the Blackhawks host the Columbus Blue Jackets (8 p.m. ET; NBCSCH, FS-O, NHL.TV).
"Murph plays a lot of minutes for us, plays a big role, particularly defensively," coach Jeremy Colliton said. "He's physical, he kills penalties, plays against top players. We'll miss him. But throughout the year you're going to be missing good players. We have to find a way to fill the void."
Murphy has scored five points (two goals, three assists) in 13 games and is averaging 22:45 of ice time per game, second on the Blackhawks behind defenseman Duncan Keith (24:09).
Forward Andrew Shaw won't play Thursday after being placed in concussion protocol. He was elbowed in the face by Stars defenseman Joel Hanley with 8:17 remaining in the second period of Chicago's 2-1 overtime win against Dallas on Tuesday. Shaw has scored four points (two goals, two assists) in 14 games.
Forward Lucas Wallmark, who was removed from NHL COVID-19 protocol Wednesday, and defenseman Adam Boqvist, who was removed from protocol Monday, will not play. -- Tracey Myers