Letang left practice early Monday for precautionary reasons after sustaining a lower-body injury in a 5-0 win at the Vancouver Canucks on Saturday. He leads Penguins defensemen with 11 points (four goals, seven assists) in nine games.
Pittsburgh went 4-0-0 on a Canadian road trip, outscoring the Toronto Maple Leafs, Edmonton Oilers, Calgary Flames and Canucks by a combined score of 23-6.
New York will try for a sweep of its three-game trip before beginning a three-game homestand against the Penguins on Thursday. The Islanders won 6-1 at the Philadelphia Flyers on Saturday and 2-1 at the Carolina Hurricanes on Sunday. They are 3-1-1 in their past five games after starting the season 2-3-0.
Islanders coach Barry Trotz will face the Penguins for the first time since the Eastern Conference Second Round of the 2018 Stanley Cup Playoffs, when he coached the Washington Capitals to a 4-2 series win.