Rickard Rakell, Anthony Mantha, Justin Brazeau and Noel Acciari scored, and Stuart Skinner made 22 saves for the Penguins (38-21-16), who have won three of four, including 8-3 at the New York Islanders on Monday.
John Gibson was pulled in a second straight start, allowing three goals on 14 shots and exiting after the first period for the Red Wings (39-27-8), who have lost four of five. Cam Talbot made 15 saves on 17 shots in relief.
Rakell put Pittsburgh ahead 1-0 at 4:10 of the first period on its first shot on goal, a wrist shot through traffic from the high slot. It was his 20th goal this season and sixth in five games.
Mantha made it 2-0 at 8:34, reaching 30 goals for the first time in the NHL. Mantha initially shot on Gibson, leaving the puck in the crease for an attempt from Connor Dewar before it slipped out of a scrum to Mantha for a wrist shot inside the left post.
Chinakhov then carried a pass from Kris Letang to just above the left circle for a quick shot past Gibson’s blocker, extending the lead to 3-0 at 18:02.
Dylan Larkin cut it to 3-1 five seconds into a power play at 3:17 of the second period, scoring his 30th goal on a wrist shot to the left of the net off a rebound from Patrick Kane.
That ended the Penguins’ run of 10 straight goals scored, including the final seven on Monday.
Brazeau pushed the lead to 4-1 at 12:23 by deflecting a point shot from Connor Clifton.
Acciari knocked down a shot from Ryan Shea to score with a wrist shot from left of the net at 12:09 of the third period for the 5-1 final.
