McDavid has scored an NHL-best 40 points in 24 games, including a League-leading 26 assists, and Matthews has scored 31 points in 20 games, including 18 goals, most in the NHL.
The game Wednesday will be the 11th time that McDavid, the No. 1 pick in the 2015 NHL Draft, and Matthews, the No. 1 selection in the 2016 NHL Draft, have faced each other; McDavid has 16 points (five goals, 11 assists) and Matthews eight points (six goals, two assists), with Toronto holding a 7-2-1 edge.
Each player is in every discussion this season regarding the Hart Trophy, awarded annually to the most valuable player in the NHL; Ted Lindsay Award, the NHLPA-voted MVP; Art Ross Trophy, for the leading point-scorer; and Rocket Richard Trophy, for most goals.