Auston Matthews had a goal and an assist, William Nylander and Kasperi Kapanen scored, and Frederik Andersen made 34 saves for the Maple Leafs (5-3-2), who are 3-1-1 in their past five games. Jake Muzzin and Andreas Johnsson each had two assists for Toronto.
"It's a recipe for giving goals up when you take penalties and turn over pucks and play in your zone, you can't win like that," Muzzin said after the Maple Leafs went 4-for-5 on the penalty kill. "We're going to play better defensively. We have to, no matter who is in net, no matter which team we are playing."
The Maple Leafs went ahead 3-2 with 17 seconds left in the second period when Nylander put in a rebound of Johnsson's shot at the side of the net.
The Blue Jackets tied it 3-3 at 10:09 of the third period when Wennberg got the rebound of Zach Werenski's second attempt and scored through Andersen's five-hole on the power play.
"Sometimes when you shoot the puck good things happen," Werenski said, "and it came right back to me after Morgan Rielly blocked the first one, so I was able to throw one down to Wennberg because he was standing there all alone, and he was able to put it in."