The Penguins have lost four in a row (0-2-2) for the first time since they lost five straight (0-4-1), which included Mike Sullivan's first four games as coach, from Dec. 11-19, 2015.
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Pittsburgh is missing eight regulars because of injury, including forward Evgeni Malkin (upper body) and defenseman Kris Letang (upper body). Sullivan said that isn't an excuse for the Penguins' recent play.
"I believe we have what it takes to win. I believe we have enough," Sullivan said. "We understand that some of the guys we have out of our lineup are difficult to replace. They're good players, so we understand that. But we also believe we have what it takes to win.
"That's where our focus needs to be. We can't control the other stuff. What we can control is the lineup that goes into the game each and every night. We believe we have enough to win games."
Chicago (49-21-7) is nine points ahead of the Minnesota Wild in the Central Division and Western Conference. The Blackhawks are five points behind the Capitals, who have one game in hand, in the race for the Presidents' Trophy.
After losing two straight games, including a 7-0 to the Florida Panthers on Saturday, Blackhawks coach Joel Quenneville said he was pleased with the response Wednesday.
"I thought we did a lot of good things," Quenneville said. "We had a great start. Some nice plays on the goals. I thought the Tampa Bay [Lightning] game [on Monday (a 5-4 overtime loss)] was like that for 30 minutes, but I liked the continuation of today's game. … I thought we played a safe and smart game with the lead."