The Buffalo Sabres fired 44 shots Craig Anderson's way, but they only beat the Ottawa Senators goaltender once in a 3-1 loss on Monday.
Zemgus Girgensons scored Buffalo's lone goal and Linus Ullmark made 27 saves.
Evan Rodrigues led the team with six shots on goal at Canadian Tire Centre. Anderson was between the pipes for his first appearance for Ottawa since Dec. 7.
Jean-Gabriel Pageau scored the game's first goal with 53.2 seconds remaining in the first period, just minutes after Ullmark stopped Connor Brown on a breakaway. On the goal, Brady Tkachuk won a battle in the corner and fed a one-timer to Pageau from the right faceoff circle, who was able to beat Ullmark.
"It felt like we took over the second half of that period," defenseman Marco Scandella told Rob Ray during the first intermission on MSG. "It's unfortunate that we gave up that goal at the end, but I like the way we're playing right now so we're just going to keep at it."
Midway through the second, Ullmark was strong again, stopping Tyler Ennis on the doorstep while shorthanded.
The Sabres tied it up with 4:48 left in the second when Girgensons redirected a bouncing backhand attempt from the halfwall by Rodrigues.
However, the Senators regained the lead 5:16 into the third period when Pageau knocked in a rebound for his second goal of the game.
And with 9:17 remaining in the third, Anderson made a tremendous save on Rodrigues, diving backwards into the crease and stopping Rodrigues' effort with his out-stretched blocker.
Brady Tkachuk was then awarded a goal when he was tripped up by Henri Jokiharju with the net empty with 1:24 remaining in regulation.
What it means
The Sabres are now 17-14-7 on the season and 6-11-4 on the road.
Jack Eichel saw his career-best 18-game personal point streak snapped. He tied Gilbert Perreault (Oct. 24 to Dec. 4, 1971) for the most consecutive games played with a point in franchise history.
It was the NHL's fifth-longest personal point streak in the last decade, trailing only Taylor Hall (26 in 2017-18), Patrick Kane (26 in 2015-16), Sidney Crosby (25 in 2010-11) and Patrick Kane (20 in 2018-19).
Victor Olofsson's six-game point streak also came to an end.
Roll the highlight film
Here's Girgensons' sixth goal of the season:
Video: BUF@OTT: Girgensons tips Rodrigues' pass home
The Sabres will have the next three days off for the League-mandated holiday break.
They're back in action on Friday when the Boston Bruins come to town to kick off a home-and-home set against the two clubs. Faceoff is scheduled for 7 p.m. Tickets are on sale now.