It's the Penguins' fifth set of back-to-backs this season. They are 0-4-0 and have been outscored 29-7 in the second game of their previous back-to-backs.
The Penguins ended a two-game losing streak (0-2-0) with a 3-2 win at the Edmonton Oilers on Wednesday.
The Flames will be without forward Jaromir Jagr for a fifth straight game. Jagr, 45, sustained a lower-body injury during a 4-2 loss to the Minnesota Wild on Oct. 21. He was placed on injured reserve Oct. 23 and was expected to miss about a week.
Jagr played the first 11 of his 24 NHL seasons for the Penguins, who selected him with the No. 5 pick of the 1990 NHL Draft. He had 1,079 points (439 goals, 640 assists) in 806 games and won the Stanley Cup in 1991 and 1992 with Pittsburgh.