Edmonton Oilers at Toronto Maple Leafs, 7 p.m. ET (NBCSN, SN, TVAS)
The McDavid vs. Matthews matchup will grab the headlines, but the bigger story could be the Oilers needing a win after a 1-3-0 start to the season.
San Jose Sharks at St. Louis Blues, 9 p.m. ET (FS-MW, NBCSCA, NHL.TV)
The Sharks continue their eight-game road trip to start the season and are looking to end a four-game losing streak (0-3-1) in St. Louis.
Minnesota Wild at Anaheim Ducks, 9:30 p.m. ET (NBCSN, FS-W)
NHL First Star of the Week Kirill Kaprizov and the Wild look to rebound after a 1-0 loss to the Ducks on Monday.
Montreal Canadiens at Vancouver Canucks, 10 p.m. ET (ESPN+, SNP, TSN2, RDS, NHL.TV)
The Canadiens have allowed two goals in their past two games after allowing five in their season opener against the Maple Leafs.
Arizona Coyotes at Vegas Golden Knights, 10 p.m. ET (ESPN+, SN360, SNE, SNO, SNW, ATTSN-RM, FS-A PLUS, NHL.TV)
The Golden Knights look to win their fourth straight game to start the season after rallying for a 4-2 victory against the Coyotes on Monday.