The Predators lead the NHL with 113 points, three ahead of the Winnipeg Jets with two games remaining. Nashville would clinch the division and conference with a win of any kind.
Nashville, 3-4-1 in its past eight games after its team-record 15-game point streak (14-0-1), also can win the Central Division with one point against the Capitals if the Jets lose to the Calgary Flames in any fashion, or if the Jets lose in regulation.
The Predators also can clinch the conference if they get one point against Washington and the Jets lose in any fashion, or if Winnipeg loses to Calgary in regulation and the Vegas Golden Knights lose to the Edmonton Oilers in any fashion.
Nashville would secure the Presidents' Trophy for most points in the League with a win and a regulation loss by the Boston Bruins to the Florida Panthers.
A win by the Predators would give them 52 victories, the most in one season in their history; Nashville also won 51 games in 2006-07.
The Capitals, 11-2-0 in their past 13 games, have clinched first place in the Metropolitan Division. Center Alex Ovechkin, who did not practice Wednesday, will be in the lineup.