John Tavares had a goal and an assist, and Tyson Barrie had two assists for Toronto. The Maple Leafs scored four goals in the second period, none at even strength: Trevor Moore scored shorthanded, and William Nylander, Matthews and Tavares scored on the power play.
Frederik Andersen made 16 saves for Toronto, which finished the preseason 5-3-0.
Jimmy Howard made 24 saves on 29 shots, and Filip Larsson made three saves in relief for Detroit, which finished the preseason 3-3-3.
The Maple Leafs open the regular season against the Ottawa Senators on Oct. 2.
The Red Wings open the regular season at the Nashville Predators on Oct. 5.
