Prior to the injury, the No. 1 selection in the 2015 NHL Draft had five goals and 12 points in 13 games and was named the NHL's rookie of the month for October.
"It's exciting, I'm excited to play again," McDavid said following practice Monday. "Anxious is probably a better word [than nervous], it feels like my first game all over again. I'm just looking forward to it."
McDavid will center the Oilers' second line between right wing Jordan Eberle and left wing Benoit Pouliot. Eberle missed the first 13 games of the season with a shoulder injury. His first game was Nov. 6 against the Pittsburgh Penguins, which was McDavid's first game out of the lineup.
"I don't think [Eberle] and I have even played a shift together before, so this will be a little different for us; it'll be a little bit of an adjustment," McDavid said. "But I'm definitely excited to play with a guy like Jordan. Obviously, Pouliot, I have a little bit of experience with, so I'm definitely excited about it."
Eberle has 11 goals and 22 points in 37 games for Edmonton (19-26-5) this season. He was the Oilers' leading scorer last season with 24 goals and 63 points in 81 games.
"I think it'll be very good, everyone knows what he is like around the net," McDavid said. "He's got those quick, great hands and has a deceiving shot that fools goalies a lot of the time. If you get him the puck in a good spot, you know he's going to finish it."
Eberle sustained a shoulder injury Sept. 29 in a preseason game against the Arizona Coyotes after taking a hit from Coyotes center Kyle Chipchura along the end boards.
"It's funny the way the year has gone that I came back the game after Connor got injured," Eberle said. "I haven't played a game with him, even in exhibition, I haven't been on the ice with him. It's good to get out there and practice, I thought we had a good intense skate today and got our wind back, and hopefully, we'll find some chemistry tomorrow."
McDavid has been practicing with the Oilers since Jan. 1. He went to practice with the Oilers' American League Hockey affiliate in Bakersfield during the NHL All-Star break. Edmonton had nine days off between games during the break.