Fleury has 453 victories in 823 NHL games (453-257-78, two ties); Joseph had 454 in 943 appearances (454-352-6, 90 ties).
The Golden Knights are 4-0-1 in their past five games and 9-2-2 in their past 13. They're playing the second of back-to-back games after defeating the San Jose Sharks 3-1 at SAP Center on Sunday.
Pavel Francouz will start for the Avalanche, who are seeking their first win in three games after going 9-1-1 in their previous 11. Colorado has won its past three games against Vegas, including a 6-1 victory at T-Mobile Arena on Oct. 25.
Colorado forward Gabriel Landeskog is expected to play his 600th NHL game. Landeskog, Colorado's captain since 2012-13, was selected with the No. 2 pick in the 2011 NHL Draft; he has 429 NHL points (184 goals, 245 assists), all with the Avalanche.