DeBoer, who is 4-2-1 with Vegas, replaced Gerard Gallant on Jan. 15 before the second game of eight straight on the road.
The Golden Knights have won three of their past four games and trail the Vancouver Canucks by two points for first place in the Pacific Division.
Carolina is coming off a 5-3 victory at the Arizona Coyotes on Thursday and is 4-2-0 in its past six games. Forward Erik Haula, who played the previous two seasons with the Golden Knights, will return to Vegas for the first time since being traded to Carolina on June 27.
Players to watch
Hurricanes forward Sebastian Aho has eight points (five goals, three assists) during a five-game point streak.
Golden Knights forward Mark Stone had five points (two goals, three assists) in a 7-2 win against the Florida Panthers on Thursday.