Guy Boucher's squad is in the midst of a six-game losing streak. In fact, the Senators haven't put up a number in the win column since their overseas road trip to Sweden earlier this month.
This will mark the first meeting between the two Atlantic Division rivals since October 30, when the Canadiens handed the Senators an 8-3 loss at the Canadian Tire Centre.
For Ottawa, this is the first of seven straight games away from the friendly confines of the nation's capital. They were last in action on Saturday, when they dropped a 2-1 decision to the New York Islanders.
The Canadiens, meanwhile, snapped the Columbus Blue Jackets' six-game winning streak on Monday night with a 3-1 win in Montreal. Brendan Gallagher, Jonathan Drouin and Andrew Shaw found the back of the net, and Carey Price turned in a 37-save performance.