Khudobin, 2-0-1 with a 2.97 goals-against average and .910 save percentage this season, started the past two games when Rask was out because of a concussion.
Rask, who will be the backup, has practiced every day since Tuesday, but coach Bruce Cassidy said the training staff, coaching staff and Rask decided it would be better for him to practice again before playing. Their next game is at home against the Los Angeles Kings on Saturday.
The Sharks will look to build off their 4-1 win at the New York Rangers on Monday. They are 2-1-0 during their five-game road trip. They had to kill six Rangers power plays in New York.