Colorado holds a one-point lead on the Arizona Coyotes with one game in hand.
The Avalanche, 6-0-1 in their past seven games, are four points behind the Dallas Stars, who hold the first wild card.
The Blues are third in the Central Division but are two points behind the Winnipeg Jets and the Nashville Predators, who are tied for first place. Winnipeg plays the Chicago Blackhawks on Monday.
St. Louis, 6-1-1 in its past eight games, is 3-0-0 against Colorado this season, with two of those wins in overtime, and can sweep a season series from the Avalanche/Quebec Nordiques for the fifth time in Blues history and first since 1991-92.