Jordan Kyrou extended his point streak to six games when he scored with a wrist shot from the top of the left circle to make it 4-1 at 1:09 of the third.
The Blues said they wanted a better showing after a 3-2 loss to the previously one-win Arizona Coyotes on Tuesday.
"Businesslike. Practice the next day was businesslike," Blues coach Craig Berube said. "I don't know if I really talk in terms of business to the players like that. But if we can become a businesslike team night in, night out, in practice and all that, that goes a long way. And you know you're going to be prepared to play the right way if you get that mindset."
NOTES:The Sharks allowed the first goal for the first time in nine games. ... The Blues are 5-0-1 their past six games against the Sharks and 11-2-3 the past 16. ... Blues defenseman Justin Faulk played in his 700th NHL game (559 with the Carolina Hurricanes and 141 with St. Louis), becoming the 33rd U.S.-born player to reach that mark. ... Kyrou has six goals, two assists during his point streak and 12 points (six goals, six assists) in 12 games against the Sharks. ... Husso's shutout streak ended at 163:02. ... The 48 shots by the Blues is their most in a regular-season game since they had 49 against the Vegas Golden Knights Oct. 12, 2017. ... The 48 shots allowed was a season high by the Sharks.