Byram has played in 15 games so far in his rookie campaign and has recorded two assists and logged a career-high 25:03 of ice time in Colorado's 3-2 victory at the Vegas Golden Knights on Feb. 16. Makar has also skated in 15 contests this season and has the reigning Calder Trophy winner has one goal and 13 helpers.
With Byram and Makar getting back into game action, defensemen Greg Pateryn and Dan Renouf will be out of the lineup.
"With Cale coming back in, I mean he's a superstar and we got to get him back in the lineup playing here, and he's healthy and we know what he can do and how he can help us," said head coach Jared Bednar. "Bo, as a young guy coming in for the most part has been real good for us, been a little bit inconsistent as you'd expect from any young player coming in, especially a D-man. But I think that we got to get him playing, get him up to speed and start watching his growth, and see if we can get him in areas where he's an impact player for us here down the stretch run and get the most out of him. He is going to be put in some different situations, and we will monitor his game."
The Avs and Wild are each riding win streaks with Colorado having recorded two points in a season-high four in a row and the Wild having won five straight. Both squads are 7-2-1 in their last 10 contests.
Colorado is one point behind Minnesota in the West Division standings, as the Avs currently hold 36 points and a 17-8-2 record while the Wild has 37 points and an 18-8-1 mark through 27 games this year.
"They are a good team, they've got a lot of depth," Byram said. "Some guys that can really shoot the puck and make plays, so we got to be ready to go. We've just kind of talked about how it's a big test for us tonight to see where we are at. We are all excited, and we will all be ready to go tonight."
Colorado is 2-1-1 against Minnesota so far this year and fell 6-2 in the squads' last meeting at Ball Arena on Feb. 24.