Givani Smith scored for Detroit with 1:43 remaining in the third period to tie it 3-3.
Jeremy Bracco scored the only goal of the shootout in the first round, and Hudson Elynuik, Matt Read and Darren Archibald scored for the Maple Leafs, who outshot the Red Wings 37-18. Michael Hutchinson played the first two periods and allowed two goals on 10 shots. He was replaced by Joseph Woll, who made seven saves in the third.
Evgeny Svechnikov and Chris Terry scored, and Bernier made 34 saves for Red Wings.
The teams end their preseason schedule against each other at Toronto on Saturday.
