Muzzin had a goal and two assists in a 6-1 win against the Anaheim Ducks on Monday, his third game with the Maple Leafs after being acquired in a trade with the Los Angeles Kings on Jan. 28. He has 216 points (52 goals, 164 assists) in 499 NHL games.
The Maple Leafs have won back-to-back games and are 3-0-1 in their past four games after going 3-7-0 in their previous 10.
Goalie Craig Anderson is expected to start for the Senators, who will try to end a four-game losing streak (0-4-0) after going 4-1-0 in their previous five games.