Forward Taylor Hall was a late scratch for what the Devils called precautionary reasons. Hall, who leads New Jersey with 25 points (six goals, 19 assists) in 30 games, can become an unrestricted free agent July 1, 2020, and is a potential trade target.
Devils coach Alain Nasreddine said he was told by management during warmups that Hall wouldn't play.
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"The guys reacted well," Nasreddine said. "I told them we got a job to do, got to go out and perform, there's two points on the line, and that's where our focus should be. I thought the guys came out ready to play.
"It's big news, I'm not going to lie. It's big news when one of the top players in the League is not dressing for your team."
Nasreddine said he didn't know if Hall would play Saturday against the Arizona Coyotes.
"I would have to talk to management," he said. "Right now, I have no answer on that question."
Nathan MacKinnon had a goal and an assist, and Valeri Nichushkin and Gabriel Landeskog scored for the Avalanche (21-8-3), who are 8-0-1 in their past nine games.