Kaapo Kakko and Chris Kreider scored for the Rangers (49-20-4), who have won four in a row and six of their past seven games.
Casey Mittelstadt scored, and Alexandar Georgiev made 23 saves for the Avalanche (46-21-6), who have lost two in a row after winning nine straight.
Nathan MacKinnon’s point streak ended at 19 games, and his season-opening home point streak ended at 35 games. He had 77 points (29 goals, 48 assists) during his home streak, which is the second-longest in NHL history. Wayne Gretzky owns the longest at 40 games (Los Angeles Kings, 1988-89).
Mittelstadt scored to make it 1-0 Colorado at 19:33 of the second period when he took a pass from Brandon Duhaime in the right circle, sliced toward the net, and scored on a snap shot far side under the blocker.
Kakko tied it 1-1 at 2:59 of the third period when he put a shot from behind the net off the back of Georgiev.
Krieder scored to make it 2-1 with a power-play goal at 9:35. Artemi Panarin’s initial shot from inside the blue line hit Vincent Trocheck in front of the net and caromed over to Krieder for the tap-in.
Colorado challenged the play for a missed hand pass on the shot but the goal was upheld following video review.
Devon Toews was credited with a goal to tie it 2-2 at 12:47 after Rangers defenseman Ryan Lindgren knocked in the rebound of Toews’ initial shot from the blue line.
Artemi Panarin and Mika Zibenejad scored in the shootout, and Shesterkin stopped Mittelstadt and Mikko Rantanen.
