GLENDALE, Ariz. -- Andre Burakovsky scored the go-ahead goal at 15:18 of the third period, and the Washington Capitals ended the Arizona Coyotes' four-game winning streak with a 4-2 victory at Gila River Arena on Thursday.
Matt Niskanen had a goal and an assist, and Jakub Vrana scored for the Capitals (16-9-3), who won for the first time in three games and are 8-2-0 in their past 10. Pheonix Copley made 27 saves.
"It's a big relief we won this game," Burakovsky said.
[WATCH: All Capitals vs. Coyotes highlights]
Christian Fischer and Lawson Crouse scored for the Coyotes (13-12-2). Adin Hill made 25 saves in his first loss and fourth start of the season.
Burakovsky, moved up to the Capitals' No. 1 line with Tom Wilson out with an upper-body injury, skated in from the neutral zone and took a wrist shot that went in off Hill's blocker to make it 3-2.
"This game is funny. Overall, I wasn't really there today, I had a tough one," Burakovsky said. "Some nights, you have 1,000 chances and can't score. Some nights, you're struggling and you get one."
Washington used different line combinations after Wilson was injured in a 5-3 loss at the Vegas Golden Knights on Tuesday, but its top two lines combined for three goals against Arizona.
Video: WSH@ARI: Vrana flicks quick wrister past Hill
"When they get an opportunity, whether they take advantage of it is up to them," coach Todd Reirden said. "We haven't had our lineup but one game, but to me, that's what makes a team; going through adversity and a number of different things is going to help us in the long run."
Alex Ovechkin scored into an empty net with three seconds left for the 4-2 final score. It was his 21st goal, tied for the NHL lead with Brayden Point of the Tampa Bay Lightning and Patrik Laine of the Winnipeg Jets.
Video: WSH@ARI: Ovechkin seals win with empty-net goal
The Coyotes went ahead 1-0 in the first period and 2-1 in the second.
"I hope our players are [mad], because the coaching staff is [mad]," coach Rick Tocchet said. "These are games you've got to win, I think. It's not the good old college try. It's 2-2 (entering the third period), at least go to overtime. We kind of just backed up, and I hate backing up when it's 2-2. … It's frustrating."
Fischer gave Arizona a 1-0 lead 4:48 into the game. Derek Stepan took the puck away from Burakovsky to set up Fischer's one-timer from the right face-off circle.
Video: WSH@ARI: Fischer one-times puck past Copley
Vrana tied it 1-1 on a wrist shot from the slot at 5:27 of the second after scoring twice against Vegas.
"Our line is creating a lot of chances, and I'm happy for that," said Vrana, who is playing on the second line with Evgeny Kuznetsov and Brett Connolly. "It's tough with the injuries we have, so we need a little more response here."
Crouse scored on the rebound of Jordan Oesterle's shot from the point to put the Coyotes ahead 2-1 at 6:59.
Niskanen tied it 2-2 with a shot that deflected off Coyotes defenseman Jakob Chychrun's leg at 16:00. Copley got his first NHL assist on the goal.
Each team failed to score on a penalty shot; Arizona's Richard Panik shot wide at 1:16 of the second period, and Hill made the save against Vrana 16 seconds into the third.
They said it
"Obviously, playing with those guys (Alex Ovechkin and Nicklas Backstrom), it's more ice time than I've had in the past this season, and I'm trying to take advantage of it. I don't think I did much to help them out there, so I just want to focus on the next game and put this one behind me." -- Capitals forward Andre Burakovsky, who wasn't pleased with his performance playing on the top line despite scoring the game-winning goal
"I thought there were plays to be made, that's what I saw. It's a winnable game." -- Coyotes coach Rick Tocchet
"They're a good team and they can score goals, and they had a little extra push. It's tied 2-2 with five, six minutes left, and we've got to find a way to lock it down. We shouldn't be backing up or doing anything different. We've just got to find a way." -- Coyotes forward Christian Fischer
Need to know
With the first of his four shots on goal in the game, Ovechkin became the eighth player in NHL history with 5,000. ... Ovechkin has nine goals and five assists during a 10-game point streak. ... The Capitals hadn't won at Arizona in regulation since Jan. 16, 2006. The Coyotes were 5-0-1 in their past six home games against them. ... Arizona forward Vinnie Hinostroza played 6:53 before leaving the game at 6:18 of the second period with a lower-body injury. ... It was the eighth game in NHL history when each team had a penalty shot. The other two games when each team failed to score occurred March 21 (Derick Brassard for the Pittsburgh Penguins and Brendan Gallagher for the Montreal Canadiens) and Nov. 21, 2015 (Reilly Smith for the Florida Panthers and Chris Kreider for the New York Rangers).
Capitals: At the Columbus Blue Jackets on Saturday (7 p.m. ET; FS-O, NBCSWA, NHL.TV)
Coyotes: Host the San Jose Sharks on Saturday (8 p.m. ET; FS-A, NBCSCA, NHL.TV)
Video: Niskanen, Burakovsky lead Caps to 4-2 victory