It will be the Blues' second game without defenseman Jay Bouwmeester, who is out indefinitely after a cardiac episode on the bench in the first period of their game against the Anaheim Ducks on Tuesday. Bouwmeester had an implantable cardioverter defibrillator (ICD) procedure to restore his heart's normal rhythm on Friday.
St. Louis, which has lost three straight (0-1-2) and is 2-5-3 in its past 10 games, leads the Colorado Avalanche by two points for first place in the Central Division.
Nashville is coming off a 5-0 win against the New York Islanders on Thursday and is three points behind the Arizona Coyotes for the second wild card into the Stanley Cup Playoffs from the Western Conference.
The Predators are 2-0-0 against the Blues this season, sweeping their previous home-and-home with a 4-2 win in St. Louis on Nov. 23 and a 3-2 shootout victory in Nashville on Nov. 25.