The Predators will attempt to extend their point streak to 14 games, which would match the longest in their history.
Nashville, 12-0-1 in their past 13 games, also can clinch with a shootout win if the Anaheim Ducks lose to the Detroit Red Wings or win a shootout, or if the Dallas Stars lose at the Ottawa Senators.
The Predators haven't lost in regulation since a 3-1 defeat against the Red Wings on Feb. 17, and can tie their record for longest point streak, when they went 9-0-5 from Feb. 12-March 9, 2016. Nashville has a point in 13 straight road games (10-0-3), matching its record set in 2015-16.
Nashville leads the Winnipeg Jets by eight points for first place in the Central Division and is seven points ahead of the Vegas Golden Knights for the best record in the Western Conference.
The Avalanche, seeking their fourth straight win and a point in their 10th straight game (6-0-3), hold the first wild card into the playoffs from the Western Conference. They are one point behind the Minnesota Wild for third place in the Central and one point ahead of the Dallas Stars, who hold the second wild card.