Nino Niederreiter, Ryan Dzingel and Andrei Svechnikov scored for Carolina.
"It's definitely great playing on the top line," said Niederreiter, who skated with Sebastian Aho and Teuvo Teravainen. "I wasn't very pleased with last season, I expected more from myself. Being out there with them is a great opportunity for me and I have to work hard enough to keep that spot."
Thomas Griess made 40 saves in his debut for the Red Wings, who were playing their first game in 310 days (also against the Hurricanes at Little Caesars Arena). Detroit was not among the 24 teams in the NHL Return to Play Plan after last season was paused March 12 due to concerns surrounding the coronavirus.
"They had a lot of shots, but I thought our guys played pretty well," Griess said. "They were boxing out in front of me, so a lot of those shots were coming from the outside. I think this first game will do everyone a lot of good. There's stuff you just can't simulate during training camp."
Aho helped give Carolina a 1-0 lead at 3:38 of the first period. He knocked a pass from Red Wings forward Dylan Larkin out of the air and sent a backhand, cross-ice pass that tipped the stick of Teravainen before getting to Niederreiter, who deked Greiss from in close.
"I just made a bad mistake with the puck and it cost us a goal," Larkin said. "We were too sloppy at the start of the game, but I thought we got more comfortable as the game went on.
"It has been 10 months without a game and everyone was so fired up that it felt like Game 7 of a playoff series out there."