Peter Holland is expected to get back in the lineup, as he took David Desharnais' spot Friday in practice.
The Rangers have won both games against the Sabres this season, including the 2018 Winter Classic in January.
Buffalo enters tonight's game with three straight losses, including a 3-0 defeat at the hands of the Montreal Canadiens last night.
Jack Eichel leads the club with 22 goals and 54 points in 59 games, followed by Ryan O'Reilly's 52 points, including a team-high 32 assists, in 73 games.
Goaltender Linus Ullmark has started two of the last three games, all of which were losses. No. 1 goaltender Robin Lehner served as the team's backup last night after missing time due to injury.