Yakupov played fewer minutes Thursday (8:30) than he did Wednesday (10:38), but Hitchcock expects to play him in more situations rather quickly.
"Yakupov's starting to understand the things we want in winning hockey," Hitchcock said. "He's starting to understand that. As he starts to gain more steam 5-on-5, we'll bleed him into the power play starting next week. He's starting to figure it out.
Alexander Steen and Magnus Paajarvi each scored a goal and Patrik Berglund had two assists for the Blues, who played their home opener after defeating the Chicago Blackhawks 5-2 on Wednesday. Jake Allen made 19 saves.
Ryan Suter and Charlie Coyle scored for Minnesota, which was playing its season opener, and Devan Dubnyk made 28 saves.
"The whole game, we couldn't get up to speed," Suter said. "They were coming and we just couldn't catch up."
Yakupov scored with 7:24 remaining in the second period to make it 2-1, and Paajarvi scored off an odd-man rush, taking Yakupov's cross-ice pass in the left circle and beating Dubnyk 4:25 into the third to give the Blues a 3-1 lead.
Coyle scored with 7:11 remaining in the game off a Jason Zucker centering pass to make it 3-2.
Steen put the Blues up 1-0 at 10:51 of the first period, his third point in two games, but Suter tied the game 1-1 at 3:03 of the second period.