It was Bertuzzi's first multigoal game since Oct. 14, 2021, when he played for the Detroit Red Wings.
Mitchell Marner had a goal and an assist, and William Nylander had three assists for the Maple Leafs (33-16-8). Ilya Samsonov made 25 saves.
Mikko Rantanen had a goal and an assist for the Avalanche (35-19-5), who had won six in a row at home. Alexandar Georgiev made 26 saves.
Nathan MacKinnon had three assists to extend his season-opening home point streak to 28 games, which is tied for the sixth-longest at any point in a season in NHL history. Wayne Gretzky owns the record at 40 games (1988-89).
Artturi Lehkonen gave Colorado a 1-0 lead at 2:16 of the first period, redirecting MacKinnon’s slap pass at the edge of the crease for a power-play goal.
Andrew Cogliano made it 2-0 at 11:07, scoring glove side off a pass from MacKinnon on a 2-on-1. MacKinnon had started the rush by skating down the right boards past Morgan Rielly, which forced TJ Brodie to slide his way.
Bertuzzi cut the lead to 2-1 with a power-play goal at 13:42 of the first. He finished a backdoor pass from Marner at the right post.
Bertuzzi scored again to tie the game 2-2 at 14:45 of the second period, swatting in the rebound of Nylander’s initial shot in the crease on a 3-on-2 rush.
Marner then put Toronto in front 3-2 at 16:48 with a wrist shot from just inside the blue line.
Rantanen tied it 3-3 at 4:41 of the third period, scoring with his own wrist shot from the blue line through traffic.
However, Bertuzzi completed the hat trick with a power-play goal at 17:09 for the 4-3 final.
