McDavid, who missed a 3-2 overtime loss to the Vegas Golden Knights on Monday because of an illness, took part in an optional skate Wednesday.
"I just had the flu," McDavid said. "I haven't been sick this year. This one hit me a little later. It is what it is, it's a long year, these things happen."
McDavid ranks second in the NHL with 96 points (33 goals, 63 assists) in 63 games behind teammate Leon Draisaitl (110 points; 43 goals, 67 assists in 70 games). He has 15 points (three goals, 12 assists) in eight games after missing six from Feb. 11-21 with a leg injury.
Kailer Yamamoto will be in the lineup after the rookie forward didn't practice Tuesday (maintenance day). He has 25 points (11 goals, 14 assists) in 26 games since being recalled from Bakersfield of the American Hockey League on Dec. 29.
The Oilers (37-24-9) are second in the Pacific Division, three points behind the Golden Knights.
"Winning games is fun and being a part of this is fun," said McDavid, the Edmonton captain. "Playing meaningful games right now is exciting, and we're in a good position and we want to keep going and put ourselves in a really good spot."
NHL.com independent correspondent Derek Van Diest contributed to this report
